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pentobarbital will decrease the level or result of pitolisant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Carefully. Pitolisant exposure is lowered by 50% if coadministered with solid CYP3A4 inducers.pentobarbital will minimize the level or effect of estropipate by affecting hepatic/intestinal enzyme CYP3